MDPHP (3′,4′-Methylenedioxy-α-pyrrolidinohexiophenone) is a stimulant of the cathinone class originally developed in the 1960s,which has been reported as a novel designer drug. It is closely related to the potent stimulant MDPV though with slightly milder effects, and has been used as an alternative in some countries following the banning of MDPV. This psycho stimulant is related to the class of pyrovalerone and MDPV (methylenedioxy pyrovalerone) in particular.
α-PiHP generally comes in the form of either a fine powder or crystallized shards which users can ingest to produce powerful but short-lived euphoric stimulant effects which are comparable to those of methamphetamine and cocaine when insufflated or vaporized. Like its research chemical cathinone predecessors, it is has gained notoriety for its tendency to induce compulsive redosing and addictive behaviors in a large percentage of its users as well the ability to readily induce delusional states and psychosis when abused.
α-PHP has a short history of use and is subject to much scrutiny by the media. It is being used and marketed as a replacement for α-PVP (known on the street as flakka) a few years following its ban, where it has come to substitute α-PVP in many parts of the world. While initially mass synthesized in Chinese industrial laboratories, a ban on α-PHP within China’s borders has forced production to nations worldwide.
Very little data exists about the pharmacological properties, metabolism, and toxicity of α-PHP. It has recently become commonly marketed alongside research chemical stimulants like NEP and Hexen as a legal, grey-market alternative to a-PVP, and commercially distributed through online research chemical vendors.
α-PVP, or alpha-Pyrrolidinovalerophenone, is a compound of the substituted cathinone and substituted pyrrolidine chemical classes. Its structure is comprised of pentanal bound to a phenyl ring at the 1 position and the nitrogen of a pyrrolidine ring at the 2 position. α-PVP acts as a potent norepinephrine-dopamine reuptake inhibitor (NDRI), similar to the designer drug MDPV.
The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects