2-Fluoromethamphetamine (2-FMA) is a novel stimulant substance of the amphetamine class that produces classical stimulant effects such as stimulation, enhanced focus and euphoria when administered. 2-FMA is part of a series of modern fluorinated amphetamine analogs that include compounds like 2-FA, 3-FA, 3-FEA and 4-FA, some of which have been gaining popularity as research chemical substitutes for traditional stimulants like amphetamine or methamphetamine.
2-Fluoromethamphetamine is commonly taken either orally or via insufflation and is reported to be highly unpleasant to vaporize. It is commonly compared to lisdexamfetamine (Vyvanse) in its duration, potency and efficacy as a study or productivity aid. Despite its popularity as a research chemical study aid, little is known about the effects that may accompany its long-term use as a substitute for prescription stimulants.
A substantial increase in adverse effects like high blood pressure and increased heart rate is often reported for dosages above the heavy dosage range.
2-Fluoromethamphetamine is sometimes sold on the online research chemical market. It is strongly advised to use harm reduction practices if using this substance.
2-Fluoromethamphetamine (2-FMA) is a synthetic molecule of the substituted amphetamine class. Molecules of the amphetamine class contain a phenethylamine core featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain with an additional methyl substitution at Rα (i.e., amphetamines are alpha-methylated phenethylamines). 2-Fluoromethamphetamine contains a methyl group bound to the terminal amine RN of the amphetamine core, a substitution it shares with methamphetamine.
2-Fluoromethamphetamine is the 2-position fluorinated analog of methamphetamine and the N-methylated homolog of 2-FA (2-fluoroamphetamine).
Although 2-FMA has not been formally studied on the same level as traditional amphetamines, it is thought that it acts as both a dopamine and norepinephrine releasing agent. This means it effectively increases the levels of the norepinephrine and dopamine in the brain by binding to and partially blocking the transporter proteins that normally remove them from the synaptic cleft. This allows dopamine and norepinephrine to accumulate within the brain, resulting in stimulating and euphoric effects.