4-MeO-DMT (4-methoxy-N,N-dimethyltryptamine) is a tryptamine derivative which has some central activity in animal tests similar to that of related psychedelic tryptamine drugs, although with significantly lower potency than either 5-MeO-DMT or 4-hydroxy-DMT (psilocin).
DMT has a relatively short duration of action, intense effects and rapid onset. For that reason, DMT was known as the “businessman’s trip” during the 1960s in the United States, as a user could access the full depth of a psychedelic experience in considerably less time than with other entheogens such as LSD or magic mushrooms. DMT can be inhaled, injected, vaped or orally ingested, and its effects depend on the dose. When inhaled or injected, the effects last a short period of time: about 5 to 15 minutes. Effects can last 3 hours or more when orally ingested along with a MAOI, such as the ayahuasca brew of many native Amazonian tribes. DMT can produce vivid “projections” of mystical experiences involving euphoria and dynamic hallucinations of geometric forms.
DMT is produced in many species of plants often in conjunction with its close chemical relatives 5-MeO-DMT and bufotenin (5-OH-DMT). DMT-containing plants are commonly used in South American shamanic practices. It is usually one of the main active constituents of the drink ayahuasca; however, ayahuasca is sometimes brewed with plants that do not produce DMT. It occurs as the primary psychoactive alkaloid in several plants including Mimosa tenuiflora, Diplopterys cabrerana, and Psychotria viridis. DMT is found as a minor alkaloid in snuff made from Virola bark resin in which 5-MeO-DMT is the main active alkaloid. DMT is also found as a minor alkaloid in bark, pods, and beans of Anadenanthera peregrina and Anadenanthera colubrina used to make Yopo and Vilca snuff in which bufotenin is the main active alkaloid. Psilocin and its precursor psilocybin, an active chemical in many psychedelic mushrooms, are structurally similar to DMT.