SGT-25 (also known as 5F-CUMYL-PINACA and sometimes sold in e-cigarette form as C-Liquid) is an indazole-3-carboxamide based synthetic cannabinoid. SGT-25 acts as a potent agonist for the cannabinoid receptors, with the original patent claiming approximately 4x selectivity for CB1, having an EC50 of <0.1 nM for human CB1 receptors and 0.37nM for human CB2receptors. In more recent assays using different techniques, 5F-CUMYL-PINACA was variously found to have an EC50 of 0.43nM at CB1 and 11.3nM at CB2, suggesting a somewhat higher CB1 selectivity of 26x, or alternatively 15.1nM at CB1 and 34.8nM at CB2 with only 2.3x selectivity, however these figures cannot be directly compared due to the different assay techniques used in each case.
Like SGT-25, has occasionally been used as a recreational drug and may be found in e-cigarette liquid additive called ‘C-Liquid’
Pharmacology: 1-(5-Fluoropentyl)-N-(2-phenylpropan-2-yl)-7-azaindole-3-carboxamide has a complex pharmacology, but it is a synthetic cannabinoid of the indazole-3-carboxamide family. It can be expected to share 5F-CUMYL-PINACA’s selectivity for the CB1receptor, in the neighbourhood of 4x that for the CB2.
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